Prevalence of the occupational disease laboratory animal allergy could be reduced if aeroallergen reduction strategies are identified.
To reduce worker exposure to Mus m 1, an allergen from laboratory mice, the effect of filter cage tops, increased room ventilation, negatively pressurized ventilated cages, and ventilated cage-changing tables were evaluated.
Aeroallergen was collected in the ambient air and in the breathing zone and quantified by using a competitive immunoassay.
When mice were housed in unventilated cages, ambient allergen was reduced from 5.1 ng/m3 with no cage top to 1.3 ng/m3 with a simple filter-sheet top and 0.8 ng/m3 with a fitted filter-bonnet top (P<. 05).
Room ventilation was increased from 6 to 10,15, and 20 air changes per hour and had little effect on aeroallergen levels and no impact on airborne particulate matter.
When mice were housed in ventilated cages, ambient allergen was significantly reduced from 1.1 ng/m3 at positive cage pressure to 0.3 ng/m3 at negative cage pressure (P<. 05).
Negative cage pressure combined with handling animals under a ventilated table reduced breathing zone allergen from 28 ng/m3 with neither control strategy in place to 9 ng/m3 (P<. 05).
Use of a ventilated table controlled bacterial contamination, measured as colony forming units, found in negatively pressurized cages. (...)
Mots-clés Pascal : Allergie, Animal laboratoire, Exposition professionnelle, Prévention, Allergène, Pneumallergène, Ventilation, Filtre, Pression négative, Animalerie, Cage, Condition travail, Homme, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Allergy, Laboratory animal, Occupational exposure, Prevention, Allergen, Aeroallergen, Ventilation, Filter, Negative pressure, Laboratory animal facility, Cage, Working condition, Human, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0105338
Code Inist : 002B06C02. Création : 16/11/1999.