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  1. Mortality in rheumatoid arthritis patients with disease onset in the 1980s.

    Article - En anglais


    Several previous studies have shown increased mortality in rheumatoid arthritis (RA) patients.

    This study investigated if this was true also for patients with disease onset in the 1980s.

    Patients and methods-The study group comprised 183 patients (67 men and 116 women) with definite RA participating in an ongoing prospective study.

    Mean age at onset of disease was 51 years, and mean duration of joint symptoms at inclusion was 11 months.

    The patients were included between 1985-89

    Seventy five per cent of the patients were rheumatoid factor (RF) positive, 85% carried the shared epitope, and 90% became erosive.

    By 1 September 1997 the number and causes of death, obtained from the death certificates, were recorded.

    Standardised mortality ratio (SMR) was calculated, comparing the observed number of deaths in the cohort with the expected number of deaths in the general population in the same area, age and sex matched.

    The predictive values of demographics, genotype, RF status, and clinical data at baseline were estimated using the Cox proportional hazards regression model.


    Eighteen patients (11 men and 7 women) had died compared with 20 expected deaths.

    SMR with 95% confidence intervals was 87 (53,136).

    There was no significant increase in the number of deaths at any time during follow up for either sex.

    RA was not the main cause of death in any of the cases. (...)

    Mots-clés Pascal : Polyarthrite rhumatoïde, Homme, Symptomatologie, Epidémiologie, Mortalité, 1980-1990, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Rheumatoid arthritis, Human, Symptomatology, Epidemiology, Mortality, 1980-1990, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0105258

    Code Inist : 002B15D. Création : 16/11/1999.