To determine the prevalence of carotid atherosclerosis and associated risk factors in women with systemic lupus erythematosus (SLE).
Carotid plaque and intima-media wall thickness (IMT) were measured by B-mode ultrasound in women with SLE.
Risk factors associated with carotid plaque and IMT were determined at the time of the ultrasound scan and included traditional cardiovascular risk factors, SLE-specific variables, and inflammation markers.
The 175 women with SLE were predominantly white (87%), with a mean age of 44.9 years (SD 11.5).
Twenty-six women (15%) had a previous arterial event (10 coronary [myocardial infarction or angina], 11 cerebrovascular [stroke or transient ischemic attack], and 5 both).
The mean ± SD IMT was 0.71 ± 0.14 mm, and 70 women (40%) had focal plaque.
Variables significantly associated with focal plaque (P<0.05) included age, duration of lupus, systolic, diastolic, and pulse pressure, body mass index, menopausal status, levels of total and low-density lipoprotein (LDL) cholesterol, fibrinogen and C-reactive protein levels, SLE-related disease damage according to the Systemic Lupus International Collaborating Clinics (SLICC) damage index (modified to exclude cardiovascular parameters), and disease activity as determined by the Systemic Lupus Activity Measure. (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Complication, Athérosclérose, Carotide, Femelle, Epidémiologie, Facteur risque, Prévalence, Imagerie ultrasonore, Exploration, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Artère pathologie, Exploration ultrason
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Complication, Atherosclerosis, Carotid, Female, Epidemiology, Risk factor, Prevalence, Ultrasound imaging, Exploration, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Cardiovascular disease, Vascular disease, Arterial disease, Sonography
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0103783
Code Inist : 002B07. Création : 16/11/1999.