To describe trends in systemic lupus erythematosus (SLE) incidence and mortality over the past 4 decades.
Using the Rochester Epidemiology Project resources, medical records were screened to identify all Rochester, Minnesota residents with any SLE-associated diagnoses, discoid lupus, positivity for antinuclear antibodies, and/or false-positive syphilis test results determined between January 1,1980 and December 31,1992.
Medical records were then reviewed using a pretested data collection form in order to identify cases of SLE according to the American College of Rheumatology 1982 revised criteria for SLE.
Drug-induced cases were excluded.
All identified SLE patients were followed up until death, migration from the county, or October 1,1997.
These data were combined with similar data from the same community obtained between 1950 and 1979, and trends in the SLE incidence and mortality over time were calculated.
Of the 430 medical records reviewed, 48 newly diagnosed cases of SLE (42 women and 6 men) were identified between 1980 and 1992.
The average incidence rate (age-and sex-adjusted to the 1970 US white population) was 5.56 per 100,000 (95% confidence interval [95% CI] 3.93-7.19), compared with an incidence of 1.51 (95% CI 0.85-2.17) in the 1950-1979 cohort.
The age-and sex-adjusted prevalence rate as of January 1,1993 was ~1.22 per 1,000 (95% CI 0.97-1.47). (...)
Mots-clés Pascal : Lupus érythémateux, Disséminé, Homme, Epidémiologie, Minnesota, Etats Unis, Amérique du Nord, Amérique, Incidence, Mortalité, Symptomatologie, Génie biomédical, Traitement, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Milieu urbain, 1950-1992
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Human, Epidemiology, Minnesota, United States, North America, America, Incidence, Mortality, Symptomatology, Biomedical engineering, Treatment, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Urban environment
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0103049
Code Inist : 002B07. Création : 16/11/1999.