Objectives-Although the primary hazard to humans associated with pesticide exposure is acute poisoning, there has been considerable concern surrounding the possibility of cancer and other chronic health effects in humans.
Given the huge volume of pesticides now used throughout the world, as well as environmental and food residue contamination leading to chronic low level exposure, the study of possible chronic human health effects is important.
Methods-This was a retrospective cohort study, analysed by general standardised mortality ratio (SMR) of licenced pesticide applicators in Florida compared with the general population of Florida.
A cohort of 33 658 (10% female) licenced pesticide applicators assembled through extensive data linkages yielded 1874 deaths with 320 250 person-years from 1 January 1975 to 31 December 1993.
The pesticide applicators were consistently and significantly healthier than the general population of Florida.
As with many occupational cohorts, the risks of cardiovascular disease and of diseases associated with alcohol and tobacco use were significantly lower, even in the subpopulations-for example, men, women, and licence subcategories.
Among male applicators, prostate cancer mortality (SMR 2.38 (95% confidence interval (95% CI) 1.83 to 3.04)) was significantly increased.
No cases of soft tissue sarcoma were confirmed in this cohort, and non-Hodgkin's lymphoma was not increased. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Pesticide, Homme, Agriculteur, Tumeur maligne, Prostate, Etude cohorte, Mortalité, Recherche rétrospective, Toxicité, Facteur risque, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Pesticides, Human, Farmer, Malignant tumor, Prostate, Cohort study, Mortality, Retrospective searching, Toxicity, Risk factor, Epidemiology, United States, North America, America, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0100780
Code Inist : 002B03G. Création : 16/11/1999.