We studied second primary cancer among 25,947 patients diagnosed with squamous cell carcinoma of the skin (SCC) in Sweden between 1958 and 1992.
In total, 5,706 patients developed a second primary cancer at any site, compared with an expected number of 2,651 [standardized incidence ratio (SIR)=2.15 ; 95% confidence interval (Cl)=2.10-2.21]. Men below 60 years of age at diagnosis of SCC had higher SIR (2.5 ; Cl=2.2-2.8) with the highest risk during the first year of follow-up (SIR=9.2 ; CI=6.9-12.2).
If second primary SCC was excluded, the SIR was reduced to 1.30 (Cl=1.25-1.34) ; the relationships by sex, age and time since diagnosis remained similar.
For skin cancer, the SIR for second SCC was markedly elevated (SIR=15.6) and the risk of malignant melanoma was elevated 3-fold.
Significantly increased risks were found for most second cancers in squamous cell epithelium : lip (SIR=5.2), respiratory organs (SIR=1.7), esophagus (SIR=1.5), cervix uteri (SIR=2.2), and vulva including vagina (SIR=2.3).
There was a generally increased risk of almost 2-fold for second cancer in hematopoietic or lymphoproliferative tissues.
Slightly increased rates (SIR=1.0-1.5) were seen for second tumors in digestive tissues.
Finally, a high SIR (SIR=5.5) was observed for second primary cancer in salivary glands.
In conclusion, patients with SCC are at increased risk to develop new primary cancer, especially in skin, squamous cell epithelial and tobacco-related tissues. (...)
Mots-clés Pascal : Carcinome épidermoïde, Peau, Facteur risque, Epidémiologie, Second cancer, Registre, Suède, Europe, Homme, Tumeur maligne
Mots-clés Pascal anglais : Squamous cell carcinoma, Skin, Risk factor, Epidemiology, Second cancer, Register, Sweden, Europe, Human, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0096725
Code Inist : 002B08A. Création : 31/05/1999.