Objective To investigate the association between migraine and ischaemic or haemorrhagic stroke in young women.
Setting Five European centres participating in the World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.
Subjects 291 women aged 20-44 years with ischaemic, haemorrhagic, or unclassified arterial stroke compared with 736 age and hospital matched controls.
Main outcome measure Self reported history of headaches.
Results Adjusted odds ratios associated with a personal history of migraine were 1.78 (95% confidence intervals, 1.14 to 2.77), 3.54 (1.30 to 9.61), and 1.10 (0.63 to 1.94) for all stroke, ischaemic stroke, and haemorrhagic stroke respectively.
Odds ratios for ischaemic stroke were similar for classical migraine (with aura) (3.81,1.26 to 11.5) and simple migraine (without aura) (2.97,0.66 to 13.5) A family history of migraine, irrespective of personal history, was also associated with increased odds ratios, not only for ischaemic stroke but also haemorrhagic stroke.
In migrainous women, coexistent use of oral contraceptives or a history of high blood pressure or smoking had greater than multiplicative effects on the odds ratios for ischaemic stroke associated with migraine alone.
Change in the frequency or type of migraine on using oral contraceptives did not predict subsequent stroke. (...)
Mots-clés Pascal : Migraine, Questionnaire, Association, Accident cérébrovasculaire, Etude cas témoin, Facteur risque, Etiopathogénie, Etude comparative, Critère âge, Homme, Evaluation, Femelle, Douleur, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Migraine, Questionnaire, Association, Stroke, Case control study, Risk factor, Etiopathogenesis, Comparative study, Age criterion, Human, Evaluation, Female, Pain, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0094995
Code Inist : 002B17A03. Création : 31/05/1999.