Vitamin K mediates the gamma-carboxylation of glutamyl residues on several bone proteins, notably osteocalcin.
High serum concentrations of undercarboxylated osteocalcin and low serum concentrations of vitamin K are associated with lower bone mineral density and increased risk of hip fracture.
However, data are limited on the effects of dietary vitamin K. Objective : We investigated the hypothesis that high intakes of vitamin K are associated with a lower risk of hip fracture in women.
We conducted a prospective analysis within the Nurses'Health Study cohort.
Diet was assessed in 72327 women aged 38-63 y with a food-frequency questionnaire in 1984 (baseline).
During the subsequent 10 y of follow-up, 270 hip fractures resulting from low or moderate trauma were reported.
Women in quintiles 2-5 of vitamin K intake had a significantly lower age-adjusted relative risk (RR : 0.70 ; 95% Cl : 0.53,0.93) of hip fracture than women in the lowest quintile (<109 mug/d), Risk did not decrease between quintiles 2 and 5 and risk estimates were not altered when other risk factors for osteoporosis, including calcium and vitamin D intakes, were added to the models.
Risk of hip fracture was also inversely associated with lettuce consumption (RR : 0.55 ; 95% CI : 0.40,0.78) for one or more servings per day compared with one or fewer servings per week), the food that contributed the most to dietary vitamin K intakes. (...)
Mots-clés Pascal : Phylloquinone, Consommation alimentaire, Ostéocalcine, Facteur risque, Fracture pathologique, Os, Hanche, Ostéoporose, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Vitamine K, Alimentation, Comportement alimentaire, Système ostéoarticulaire, Système ostéoarticulaire pathologie, Traumatisme, Ostéopathie, Adulte, Homme, Femelle
Mots-clés Pascal anglais : Phylloquinone, Food intake, Osteocalcin, Risk factor, Pathologic fracture, Bone, Hip, Osteoporosis, Epidemiology, United States, North America, America, Vitamin K, Feeding, Feeding behavior, Osteoarticular system, Diseases of the osteoarticular system, Trauma, Bone disease, Adult, Human, Female
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0094630
Code Inist : 002B15A. Création : 31/05/1999.