The objective of this study was to analyze the role of some trace metals in the immune system of nonallergic or atopic men.
One of these elements (Zn) is essential for immune function, whereas others, present in the urban environment, are known to be allergenic (Ni and Cr) or toxic (Pb).
Serum levels of interleukin (IL) 2,4,5, and 13 and of interferon-gamma and immunoglobulins, blood lymphocyte subsets, blood concentrations of Pb and Zn, serum levels of Zn, and urinary Cr and Ni concentrations were determined in 17 nonallergic men (mean age 34 years) and 17 healthy nonsymptomatic atopic men living in urban areas.
The mean blood concentration of Pb (a marker of exposure to toxic agents) was 11 mug/dl in both groups, which showed similar levels of blood Zn and of urinary Ni and Cr, whereas the serum Zn concentration was lower in the atopic group.
Serum IgE levels were much higher in atopic men than in nonallergics, whereas serum IL-2, IL-5, and IL-13 concentrations were lower, possibly due to binding to tissue receptors and cells.
Moreover, in atopic subjects, numbers of blood CD4+-CD45RO- « virgin » lymphocytes were significantly lower and the CD4+-CD45RO+/CD4+-CD45RO-ratio was more elevated, indicating an activation of the immune system.
Serum IgE levels of atopic men, in contrast to those of nonallergic subjects, were correlated with CD19+and CD5--CD19+B lymphocytes. (...)
Mots-clés Pascal : Exposition, Environnement, Zone urbaine, Homme, Elément trace, Surveillance biologique, Liquide biologique, Sang, Urine, Marqueur biologique, Système immunitaire, Atopie, Sous population cellulaire, Lymphocyte, Métal
Mots-clés Pascal anglais : Exposure, Environment, Urban area, Human, Trace element, Biological monitoring, Biological fluid, Blood, Urine, Biological marker, Immune system, Atopy, Cell subpopulation, Lymphocyte, Metal
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0093411
Code Inist : 002B03L05. Création : 31/05/1999.