Exposure-response relationships in rhinitis and conjunctivitis caused by methyltetrahydrophthalic anhydride.
To examine exposure-response relationships in the occurrence of symptoms of the eyes and airways in workers exposed to methyltetrahydrophthalic anhydride (MTHPA).
A population of 11 workers from 2 condenser plants (A and B) using epoxy resin with MTHPA underwent a questionnaire survey and serology investigations, and data obtained on 95 subjects in assembly and inspection lines were analyzed for this study.
In all, 24 (65%) of 37 workers in plant A and 38 (66%) of 58 workers in plant B had positive MTHPA-specific IgE.
The air levels of MTHPA detected in assembly and inspection lines were higher in plant A than in plant B (geometric mean 25.5-63.9 and 4.93-5.49 mug/m3. respectively).
IgE-sensitized workers in each plant had significantly (P<0.05) more complaints regarding the eyes and nose than did unsensitized workers, suggesting that there is an IgE-mediated mechanism in most of these symptoms.
The sensitized workers in plant A had higher frequencies for symptoms of the eyes, nose, and pharynx than did those in plant B (P<0.02).
Furthermore, only 15% of persons often displayed work-related symptoms among the 20 symptomatic workers in plant B as compared with 73% of the 26 symptomatic workers in plant A (P<0.0001).
These results can be explained by the difference in the MTHPA levels measured in the lines between the two plants. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Benzo[c]furane-1,3-dione(1,3-dihydro), Conjonctivite, Homme, Rhinite, Allergie, Epoxyde résine, Industrie électrique, Surveillance biologique, Liquide biologique, Sang, Marqueur biologique, IgE, Teneur air ambiant, Toxicité, Oeil pathologie, Conjonctive pathologie, ORL pathologie, Nez pathologie, Immunopathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Benzo [c] furan-1,3dione(1,3-dihydro), Conjunctivitis, Human, Rhinitis, Allergy, Epoxy resin, Electric power industry, Biological monitoring, Biological fluid, Blood, Biological marker, IgE, Ambient air concentration, Toxicity, Eye disease, Conjunctiva disease, ENT disease, Nose disease, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0092773
Code Inist : 002B03L06. Création : 31/05/1999.