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  1. Exposure-response relationships in rhinitis and conjunctivitis caused by methyltetrahydrophthalic anhydride.

    Article - En anglais

    Objective 

    To examine exposure-response relationships in the occurrence of symptoms of the eyes and airways in workers exposed to methyltetrahydrophthalic anhydride (MTHPA).

    Methods 

    A population of 11 workers from 2 condenser plants (A and B) using epoxy resin with MTHPA underwent a questionnaire survey and serology investigations, and data obtained on 95 subjects in assembly and inspection lines were analyzed for this study.

    Results 

    In all, 24 (65%) of 37 workers in plant A and 38 (66%) of 58 workers in plant B had positive MTHPA-specific IgE.

    The air levels of MTHPA detected in assembly and inspection lines were higher in plant A than in plant B (geometric mean 25.5-63.9 and 4.93-5.49 mug/m3. respectively).

    IgE-sensitized workers in each plant had significantly (P<0.05) more complaints regarding the eyes and nose than did unsensitized workers, suggesting that there is an IgE-mediated mechanism in most of these symptoms.

    The sensitized workers in plant A had higher frequencies for symptoms of the eyes, nose, and pharynx than did those in plant B (P<0.02).

    Furthermore, only 15% of persons often displayed work-related symptoms among the 20 symptomatic workers in plant B as compared with 73% of the 26 symptomatic workers in plant A (P<0.0001).

    These results can be explained by the difference in the MTHPA levels measured in the lines between the two plants. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Benzo[c]furane-1,3-dione(1,3-dihydro), Conjonctivite, Homme, Rhinite, Allergie, Epoxyde résine, Industrie électrique, Surveillance biologique, Liquide biologique, Sang, Marqueur biologique, IgE, Teneur air ambiant, Toxicité, Oeil pathologie, Conjonctive pathologie, ORL pathologie, Nez pathologie, Immunopathologie

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Benzo [c] furan-1,3dione(1,3-dihydro), Conjunctivitis, Human, Rhinitis, Allergy, Epoxy resin, Electric power industry, Biological monitoring, Biological fluid, Blood, Biological marker, IgE, Ambient air concentration, Toxicity, Eye disease, Conjunctiva disease, ENT disease, Nose disease, Immunopathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0092773

    Code Inist : 002B03L06. Création : 31/05/1999.