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  1. Occupational chronic exposure to organic solvents. XVII. Ambient and biological monitoring of workers exposed to xylenes.

    Article - En anglais

    Objective 

    Ambient-air and biological monitoring of occupational xylene exposure were carried out on 2 groups of workers (13 and 10 men, respectively) exposed to a mixture of xylenes during the production of paints or during spraying.

    Methods 

    Personal ambient-air monitoring was performed for one complete work shift.

    Blood and urine samples were collected directly at the end of the shift.

    Biological monitoring was based on the determination of the concentration of xylenes in blood and on the quantification of the sum of the three methylhippuric acids in urine.

    Results 

    Average xylene ambient-air concentrations were 29 ppm (production) and 8 ppm (spraying), ranging from 5 to 58 ppm and from 3 to 21 ppm, respectively.

    The concentrations of xylenes in blood ranged from 63 to 715 mug/l and from 49 to 308 mug/l, with average values being 380 and 130 mug/l, respectively.

    Accordingly, the workers engaged in paint production also excreted more methylhippuric acids in their urine (average 1221 mg/l, range 194-2333 mg/l) than did the sprayers (average 485 mg/l, range 65 1633 mg/l).

    Discussion 

    Our results as well as a literature review indicate that occupational xylene exposure on average barely exceeds the threshold limit value of 100 ppm as proposed by both American and German institutions. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Xylène, Solvant organique, Homme, Teneur air ambiant, Lieu travail, Industrie chimique, Surveillance biologique, Marqueur biologique, Liquide biologique, Urine, Hippurique acide

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Xylene, Organic solvent, Human, Ambient air concentration, Work place, Chemical industry, Biological monitoring, Biological marker, Biological fluid, Urine, Hippuric acid

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0092257

    Code Inist : 002B03L04. Création : 31/05/1999.