In a factory producing synthetic fibers the hepatotoxic effects of the solvent N, N-di-methylformamide (DMF) were investigated in 126 male employees, especially with regard to the combination effects of DMF exposure and ethyl alcohol consumption.
A collective of similar structure from the same factory served as a control collective.
Reference is made to the results of air measurements and biological monitoring presented in a previous publication.
The DMF concentrations in the air ranged from<0.1 (detection limit) to 37.9 ppm (median 1.2 ppm).
Concentrations of the DMF metabolite N-methylformamide (NMF) in urine were 0.05-22.0 mg/l (preshift) and 0.9-100.0 mg/l (postshift), corresponding to 0.02-44.6 mg/g creatinine (preshift) and 0.4-62.3 mg/g creatinine (postshift).
A standardized anamnesis was drawn up for relevant previous illnesses and other factors influencing liver function.
The laboratory tests included parameters especially relevant to the liver (e.g., AST, ALT, gamma-GT, hepatitis B and C antibodies, and carbohydrate-deficient transferrin).
The results indicate a statistically significant toxic influence of DMF on liver function.
Alcohol has a synergistic effect.
The effects of DMF and those of alcohol are dose-dependent.
Under the existing workplace conditions the hepatotoxic effects of alcohol are more severe than those of DMF. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, DMF, Industrie textile, Fonction hépatique, Toxicité, Teneur air ambiant, Surveillance biologique, Facteur risque, Ethanol, Alcoolisme, Homme, Etude cohorte
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, N,N-Dimethylformamide, Textile industry, Liver function, Toxicity, Ambient air concentration, Biological monitoring, Risk factor, Ethanol, Alcoholism, Human, Cohort study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0092256
Code Inist : 002B03L06. Création : 31/05/1999.