Antineutrophil cytoplasmic antibodies in primary Sjögren's syndrome : Prevalence and clinical significance.
To evaluate the prevalence of cytoplasmic (c) and perinuclear (p) antineutrophil cytoplasmic antibodies (ANCA) in patients with primary Sjögren's syndrome (SS), and to correlate the presence of ANCA with extraglandular and immunological manifestations related to SS.
In a cross-sectional study, we included 82 consecutive patients (75 female and seven male ; mean age 61 yr ; range 33-87 yr) attending our unit.
All patients fulfilled four or more of the diagnostic criteria for SS proposed by the European Community Study Group in 1993.
Extraglandular manifestations such as arthralgia and/or arthritis, Raynaud's phenomenon, autoimmune thyroiditis, peripheral neuropathy, renal involvement and cutaneous vasculitis were also recorded.
Serum samples were examined by indirect immunofluorescence (IIF) and by ELISA using as substrates myeloperoxidase (MPO) and proteinase 3 (PR3).
ANCA were detected in nine (11%) patients :
Seven had pANCA and two an atypical pattern.
These two atypical ANCA became cANCA when paraformaldehyde fixation was applied.
ELISA findings showed that two patients had antibodies against MPO, and no patient had antibodies to PR3.
The most common extraglandular manifestations in the ANCA-positive patients were articular involvement in six (66%) patients, peripheral neuropathy in five (55%), Raynaud's phenomenon in four (44%) and cutaneous vasculitis in four (44%). (...)
Mots-clés Pascal : Sjogren syndrome, Symptomatologie, Analyse corrélation, Epidémiologie, Prévalence, Sérum, Immunofluorescence indirecte, Technique ELISA, Exploration, Anticorps anticytoplasme polynucléaire neutrophile, Homme, Oeil pathologie, Stomatologie, Maladie système, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Sjogren syndrome, Symptomatology, Correlation analysis, Epidemiology, Prevalence, Serum, Indirect immunofluorescence, ELISA assay, Exploration, Antineutrophil cytoplasmic antibody, Human, Eye disease, Stomatology, Systemic disease, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0091793
Code Inist : 002B07. Création : 31/05/1999.