Background Cost effective use of new vaccines against pneumococcal disease in children requires detailed information about the local epidemiology of pneumococcal infections.
Methods Data on 393 culture-confirmed cases of invasive pneumococcal infection in children (<17 years) hospitalized in Swiss paediatric clinics were collected retrospectively for the years 1985-1994.
Results Meningitis (42%) was most frequent, followed by pneumonia (28%) and bacteraemia (26%). The overall annual incidence was 2.7 cases per 100 000 children<17 years old and 11 cases per 100 000 children<2 years old.
Annual incidence rates were stable over the study period.
Lethality was high for meningitis (8.6%) and bacteraemia (8.9%). A history of basal skull fracture was reported in 3.3% of children with pneumococcal meningitis.
Residence in a rural region was associated with an increased risk of pneumococcal infection (relative risk=1.45. 95% confidence interval : 1.01-2.00).
Conclusions Paediatric, invasive pneumococcal disease seems to be less frequent in Switzerland than in other European and non-European countries.
This may be due to differences in diagnostic strategies and lower frequency of risk factors such as the use of day care.
Children with a history of basal skull fracture are at increased risk for pneumococcal meningitis. (...)
Mots-clés Pascal : Pneumococcie, Streptococcie, Bactériose, Infection, Surveillance sanitaire, Epidémiologie, Incidence, Evolution, Enfant, Homme, Adolescent, Suisse, Europe
Mots-clés Pascal anglais : Pneumococcal infection, Streptococcal infection, Bacteriosis, Infection, Sanitary surveillance, Epidemiology, Incidence, Evolution, Child, Human, Adolescent, Switzerland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0087507
Code Inist : 002B05B02N. Création : 31/05/1999.