Increased gallstone prevalence and incidence in cirrhosis have already been reported in different series, including a limited number of patients with cirrhosis.
To evaluate the frequency of gallstones and related risk factors in a large series of patients with cirrhosis.
The cross-sectional study involved 1010 patients with cirrhosis related to alcohol abuse, chronic viral infection, or miscellaneous causes (42%, 48%, and 10%, respectively) in Child class A, B, or C (48%, 36%, and 16%, respectively).
In the longitudinal study gallstone development was monitored ultrasonographically in 618 patients free of gallstones at enrollment.
The overall prevalence of gallstone (s) was 29.5% and increased significantly with age without differences according to sex or cause of cirrhosis.
Multiple logistic regression analysis showed that only Child classes B and C were significantly related to a higher risk of gallstone (odds ratio, 1.63 for class C vs class A and 1.91 for class B vs class A ; P=001).
During a mean ± SD follow-up of 50 months ± 9 months, 141 (22.8%) of 618 patients developed gallstone (s), with an estimated cumulative probability of 6.5%, 18.6%, 28.2%, and 40.9% at 2,4,6, and 8 years, respectively.
Multivariate analysis showed that Child class (hazard ratio, 2.8 for class C vs class A and 1.8 for class B vs class A ; P=002 and P=001, respectively) and high-body mass index (hazard ratio, 1. (...)
Mots-clés Pascal : Cirrhose, Epidémiologie, Lithiase, Vésicule biliaire, Prévalence, Incidence, Facteur risque, Etude transversale, Etude longitudinale, Italie, Europe, Adulte, Homme, Personne âgée, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie
Mots-clés Pascal anglais : Cirrhosis, Epidemiology, Lithiasis, Gallbladder, Prevalence, Incidence, Risk factor, Cross sectional study, Follow up study, Italy, Europe, Adult, Human, Elderly, Digestive diseases, Hepatic disease, Biliary tract disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0087483
Code Inist : 002B30A01A2. Création : 31/05/1999.