Elevated homocysteine level increases vascular disease risk.
Most data are based on subjects younger than 60 years ; data for the elderly are more limited.
We examined the relationship of homocysteine level to incident myocardial infarction and stroke among older subjects in a nested case-control study.
Subjects were participants in the Rotterdam Study, a cohort study among 7983 subjects residing in the Ommoord district of Rotterdam, the Netherlands.
Baseline examinations were performed from March 1,1990, to July 31,1993.
The analysis is restricted to myocardial infarction and stroke that occurred before December 31,1994.
One hundred four patients with a myocardial infarction and 120 with a stroke were identified with complete data.
Control subjects consisted of a sample of 533 subjects drawn from the study base, free of myocardial infarction and stroke.
Nonfasting total homocysteine levels were measured.
Results were adjusted for age and sex.
The risk of stroke and myocardial infarction increased directly with total homocysteine.
The linear coefficient suggested a risk increase by 6% to 7% for every 1-mumol/L increase in total homocysteine.
The risk by quintiles of total homocysteine level was significantly increased only in the group with levels above 18.6 mumol/L (upper quintile) : odds ratios were 2.43 (95% confidence interval, 1.11-5.35) for myocardial infarction and 2.53 (95% confidence interval, 1.19-5.35) for stroke. (...)
Mots-clés Pascal : Infarctus, Myocarde, Facteur risque, Accident cérébrovasculaire, Epidémiologie, Homocystéine, Plasma sanguin, Etude comparative, Hypertension artérielle, Association, Pays Bas, Europe, Personne âgée, Homme, Adulte, Aminoacide soufré, Thiol, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, Risk factor, Stroke, Epidemiology, Blood plasma, Comparative study, Hypertension, Association, Netherlands, Europe, Elderly, Human, Adult, Sulfur containing aminoacid, Thiol, Cardiovascular disease, Coronary heart disease, Myocardial disease, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0087001
Code Inist : 002B30A01A2. Création : 31/05/1999.