Background The objective of the investigation was to test the hypothesis that exposure to nitrogen dioxide (NO2) has a causal influence on the occurrence of bronchial obstruction in children below 2 years of age.
Methods A nested case-control study with 153 one-to-one matched pairs was conducted within a cohort of 3754 children born in Oslo in 1992/93.
Cases were children who developed >=2 episodes of bronchial obstruction or one episode lasting>4 weeks.
Controls were matched for date of birth.
Exposure measurements were performed in the same 14-day period within matched pairs.
The NO2 exposure was measured with personal samplers carried close to each child and by stationary samplers outdoors and indoors.
Results Few children (4.6%) were exposed to levels of NO2 >= 30 mug/m3 (average concentration during a 14-day period).
In the 153 matched pairs, the mean level of NO2 was 15.65 mug/m3 (± 0.60, SE) among cases and 15.37 (± 0.54) among controls (paired t=0.38, P=0.71).
Conclusions The results suggest that NO2 exposure at levels observed in this study has no detectable effect on the risk of developing bronchial obstruction in children below 2 years of age.
Mots-clés Pascal : Asthme, Obstruction, Bronche, Azote dioxyde, Pollution air, Trafic routier, Toxicité, Epidémiologie, Facteur risque, Enfant, Homme, Norvège, Europe, Santé et environnement, Etude cas témoin, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Bronche pathologie, Zone urbaine
Mots-clés Pascal anglais : Asthma, Obstruction, Bronchus, Nitrogen dioxide, Air pollution, Road traffic, Toxicity, Epidemiology, Risk factor, Child, Human, Norway, Europe, Health and environment, Case control study, Respiratory disease, Obstructive pulmonary disease, Bronchus disease, Urban area
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0086928
Code Inist : 002B30A02A. Création : 31/05/1999.