Cardiovascular disease in insulin dependent diabetes mellitus : similar rates but different risk factors in the US compared with Europe.
Background Cardiovascular disease (CVD) in insulin dependent diabetes mellitus (IDDM) has been linked to renal disease.
However, little is known concerning international variation in the correlations with hyperglycaemia and standard CVD risk factors.
Methods A cross-sectional comparison was made of prevalence rates and risk factor associations in two large studies of IDDM subjects : the Pittsburgh Epidemiology of Diabetes Complications Study (EDC) and the EURODIAB IDDM Complications Study from 31 centres in Europe.
Subgroups of each were chosen to be comparable by age and duration of diabetes.
The EDC population comprises 286 men (mean duration 20. years) and 281 women (mean duration 19.9 years) ; EURODIAB 608 men (mean duration 18.1 years) and 607 women (mean duration 18.9 years).
The mean age of both populations was 28 years.
Cardiovascular disease was defined by a past medical history of myocardial infarction, angina, and/or the Minnesota ECG codes (1.1-1.3,4.1-4.3,5.1-5.3,7.1).
Results Overall prevalence of CVD was similar in the two populations (i.e. men 8.6% versus 8.0%, women 7.4% versus 8.5%, EURODIAB versus EDC respectively), although EDC women had a higher prevalence of angina (3.9% versus 0.5%, P<0.001).
Multivariate modelling suggests that glycaemic control (HbA1c) is not related to CVD in men.
Age and high density lipoprotein cholesterol predict CVD in EURODIAB, while triglycerides and hypertension predict CVD in EDC. (...)
Mots-clés Pascal : Diabète insulinodépendant, Appareil circulatoire pathologie, Hyperglycémie, Epidémiologie, Facteur risque, Prévalence, Homme, Etats Unis, Amérique du Nord, Amérique, Glucose, Europe, Etude multicentrique, Endocrinopathie, Immunopathologie, Maladie autoimmune, Etude comparative
Mots-clés Pascal anglais : Insulin dependent diabetes, Cardiovascular disease, Hyperglycemia, Epidemiology, Risk factor, Prevalence, Human, United States, North America, America, Glucose, Europe, Multicenter study, Endocrinopathy, Immunopathology, Autoimmune disease, Comparative study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0086924
Code Inist : 002B21E01A. Création : 31/05/1999.