Background Fibrinogen and factor VII activity are known to be related to atherosclerosis and coronary heart disease, but population differences in clotting factors and modifiable characteristics that influence their levels have not been widely explored.
Methods This paper examines correlates of plasma fibrinogen concentration and factor VII activity in 2443 men and women aged 35-64 in random samples selected from the residents in two districts in urban Warsaw (618 men and 651 women) and from rural Tarnobrzeg Province (556 men and 618 women) screened in 1987-1988, and assesses which characteristics might explain urban-rural differences.
Fibrinogen and factor VII activity were determined using coagulation methods.
Results Fibrinogen was 12.9 mg/dl higher in men and 14.1 mg/dl higher in women in Tarnobrzeg compared to Warsaw.
Factor VII activity was higher in Warsaw (9.2% in men and 15.3% in women).
After adjustment for selected characteristics, fibrinogen was higher in smokers compared to non-smokers by 28 mg/dl in men and 22 mg/dl in women.
In women, a 15 mg/dl increase in HDL-cholesterol was associated with a 10 mg/dl decrease in fibrinogen (P<0.01).
After adjustment for other variables, a higher factor VII activity in Warsaw remained significant (a difference of 9.4% in men and 14.8% in women).
Lower fibrinogen in Warsaw remained significant only in women (15.4 mg/dl difference). (...)
Mots-clés Pascal : Cardiopathie coronaire, Athérosclérose, Fibrinogène, Taux, Plasma sanguin, Proconvertine, Activité biologique, Mode de vie, Epidémiologie, Facteur risque, Homme, Zone rurale, Zone urbaine, Etude comparative, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Pologne, Europe
Mots-clés Pascal anglais : Coronary heart disease, Atherosclerosis, Fibrinogen, Rate, Blood plasma, Factor VII, Biological activity, Life style, Epidemiology, Risk factor, Human, Rural area, Urban area, Comparative study, Cardiovascular disease, Vascular disease, Poland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0084787
Code Inist : 002B12A03. Création : 31/05/1999.