Controversy continues as to whether traumatic brain injury is a risk factor for Alzheimer's disease.
The authors examined a related hypothesis that among persons with traumatic brain injury who develop Alzheimer's disease, time to onset of the disease is reduced.
They used data on all documented episodes of traumatic brain injury that occurred from 1935 to 1984 among Olmsted County, Minnesota, residents.
Community-based medical records were used to follow traumatic brain injury cases who were aged 40 years or older at last contact prior to June 1,1988, for Alzheimer's disease until last contact, death, or June 1,1988.
The test of the hypothesis was restricted to those cases who developed Alzheimer's disease.
The expected time to onset of Alzheimer's disease was derived from a life table constructed by using age-of-onset distributions within sex groups for a previously identified cohort of Rochester, Minnesota, Alzheimer's disease incidence cases without a history of head trauma.
The authors found that of the 1,283 traumatic brain injury cases followed, 31 developed Alzheimer's disease, a number similar to that expected (standardized incidence ratio=1.2,95% confidence interval 0.8-1.7).
However, the observed time from traumatic brain injury to Alzheimer's disease was less than the expected time to onset of Alzheimer's disease (median=10 vs. 18 years, p=0.015). (...)
Mots-clés Pascal : Démence Alzheimer, Homme, Facteur risque, Traumatisme, Crânioencéphalique, Etude statistique, Etude cohorte, Epidémiologie, Minnesota, Etats Unis, Amérique du Nord, Amérique, Temps établissement, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Maladie dégénérative, Système ostéoarticulaire pathologie, Crâne pathologie
Mots-clés Pascal anglais : Alzheimer disease, Human, Risk factor, Trauma, Craniocerebral, Statistical study, Cohort study, Epidemiology, Minnesota, United States, North America, America, Onset time, Nervous system diseases, Central nervous system disease, Cerebral disorder, Degenerative disease, Diseases of the osteoarticular system, Skull disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0082030
Code Inist : 002B17G. Création : 31/05/1999.