Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection.
Objectives-To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis C virus (HCV) infection.
Methods-Forty nine Korean patients with HCV infection were recruited.
The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HCV genotype was determined by polymerase chain reaction with genotype specific primer.
The prevalence of cryoglobulin was 59% in Korean HCV patients and the concentration of cryoglobulin was 9.8 (7.9) g/l (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HCV patients with cryoglobulinaemia and they were all type III.
There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia.
The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia.
There was no difference in HCV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia.
Clinical features of HCV patients were as follows : arthralgia/arthritis (35%), cutaneous manifestation (37%), Raynaud's phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Association, Cryoglobulinémie, Epidémiologie, Prévalence, Symptomatologie, Arthrite, Arthralgie, Homme, Rhumatisme inflammatoire, Coréen, Appareil digestif pathologie, Foie pathologie, Système ostéoarticulaire pathologie, Arthropathie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Association, Cryoglobulinemia, Epidemiology, Prevalence, Symptomatology, Arthritis, Arthralgia, Human, Inflammatory joint disease, Korean, Digestive diseases, Hepatic disease, Diseases of the osteoarticular system, Arthropathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0081536
Code Inist : 002B05C02G. Création : 31/05/1999.