logo BDSP

Base documentaire

  1. Vasoactive intestinal polypeptide secreting islet cell tumors : A 15-year experience and review of the literature. Discussion.

    Article, Communication - En anglais

    Annual Meeting of the American Association of Endocrine Surgeons. Orlando, FL, USA, 1998/04/26.


    Vasoactive intestinal polypeptide (VIP) - secreting tumors of the pancreas represent a rare subtype of pancreatic islet cell tumors with an estimated incidence of 0.2 to 0.5 per million per year.

    We provide data on a relatively large series of patients with VIP-secreting tumors and review current literature regarding this specific entity.


    A retrospective review was performed of all patients with VIP-secreting tumors of the pancreas treated from 1977 to 1992 at our institution.

    Presenting signs, symptoms, mode of diagnosis, extent of disease, surgical resectability, tumor size, treatments, hormone levels, and survival were assessed.


    Eighteen patients were identified, 9 male and 9 female.

    Ages ranged from 23 to 74 years (mean 51 years).

    Secretory diarrhea was the most common symptom, occurring in 16 of 18 patients (89%). The most common tumor location was the tail of the pancreas (9 patients).

    Fourteen patients (78%) had liver metastasis at diagnosis.

    Curative resections were attempted in only 5 patients (28%). The mean survival was 3.6 years with the longest disease-free survival being 15 years and longest overall survival 15 years.


    VIP-secreting tumors are extremely rare entities and usually metastatic at the time of diagnosis.

    Despite advanced disease, these patients can have extended survival.

    Mots-clés Pascal : Ilot Langerhans, Cellule tumorale, Incidence, VIP, Exploration clinique, Etude longitudinale, Revue bibliographique, Diagnostic, Homme, Endocrinopathie, Pancréas endocrine pathologie, Tumeur, Neuropeptide, Hormone peptide, Hormone gastrointestinale

    Mots-clés Pascal anglais : Langerhans islet, Tumor cell, Incidence, Vasoactive intestinal peptide, Clinical investigation, Follow up study, Bibliographic review, Diagnosis, Human, Endocrinopathy, Endocrine pancreatic diseases, Tumor, Neuropeptide, Peptide hormone, Gastrointestinal hormone

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0076669

    Code Inist : 002B21E02. Création : 31/05/1999.