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  1. Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography.

    Article - En anglais

    Background Angiographic studies of the regression of coronary artery disease are invasive and costly, and they permit only limited assessment of changes in the extent of atherosclerotic disease.

    Electron-beam computed tomography (CT) is noninvasive and inexpensive.

    The entire coronary-artery tree can be studied during a single imaging session, and the volume of coronary calcification as quantified with this technique correlates closely with the total burden of atherosclerotic plaque.

    Methods We conducted a retrospective study of 149 patients (61 percent men and 39 percent women ; age range, 32 to 75 years) with no history of coronary artery disease who were referred by their primary care physicians for screening electron-beam CT.

    All patients underwent base-line scanning and follow-up assessment after minimum of 12 months (range, 12 to 15), and a volumetric calcium score was calculated as estimate of the total burden of plaque.

    Treatment with 3-hydroxy-3-methylgiutaryl coenzyme A (HMG-CoA) reductase inhibitors was begun at the discretion of the referring physician.

    Serial measurements of low-density lipoprotein (LDL) cholesterol were obtained, and the change in the calcium-volume score was correlated with average LDL cholesterol levels.

    Results One hundred five patients (70 percent) received treatment with HMG-CoA reductase inhibitors, and 44 patients (30 percent) did not. (...)

    Mots-clés Pascal : Cardiopathie coronaire, Diagnostic, Faisceau électronique, Tomographie tridimensionnelle, Traitement, Corrélation, Cholestérol LDL, Athérosclérose, Etude comparative, Analyse statistique, Efficacité traitement, Prévention, Secondaire, Adulte, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Biologie clinique, Inhibiteur HMG-CoA réductase

    Mots-clés Pascal anglais : Coronary heart disease, Diagnosis, Electron beam, Tridimensional tomography, Treatment, Correlation, Cholesterol LDL, Atherosclerosis, Comparative study, Statistical analysis, Treatment efficiency, Prevention, Secondary, Adult, Human, Cardiovascular disease, Vascular disease, Clinical biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0075684

    Code Inist : 002B12A03. Création : 31/05/1999.