Carcinoids of unknown origin : Comparative analysis with foregut, midgut, and hindgut carcinoids. Discussion.
Annual Meeting of the American Association of Endocrine Surgeons. Orlando, FL, USA, 1998/04/26.
Carcinoids are rare neuroendocrine tumors typically arising in the gastrointestinal tract.
A significant percentage of these tumors presen as metastatic disease of unknown primary site.
The aim of this study was to better define the functional and clinical characteristics of carcinoids of unknown primary (CUP) site.
This study examines the hormonal activity, clinical characteristics, and survival of 434 patients with carcinoids originating in the foregut, midgut, hindgut, or unknown location.
The 143 patients with CUP were compared with the other groups with regard to presenting characteristics, diagnostic tests and therapeutic modalities used, hormonal activity, and survival.
The hormone levels (urinary 5-hydroxyindoleacetic acid and serotonin, serum and platelet serotonin) of CUP were not significantly different from midgut carcinoids with metastatic disease.
Although survival with CUP was shorter than with carcinoids with identified primaries (10-year survivals of 22% vs 62%, 50%, and 48% for foregut, midgul, and hindgut, respectively), the survival curve for CUP was quite similar to that of patients with midgut carcinoids with distan t disease (10-year survival of 22% vs 28%). Conclusions.
CUP are similar to midgut carcinoids presenting with melastatic disease with regard to hormone production and survival.
Like other carcinoids, CUP can be an indolent disease process with gradual progression over decades.
Mots-clés Pascal : Tumeur carcinoïde, Tumeur neuroendocrinienne, Etude comparative, Régulation hormonale, Exploration clinique, Caractéristiques, Intestin antérieur, Intestin moyen, Intestin postérieur, Survie, Homme, Tumeur, Appareil digestif pathologie, Intestin pathologie, Biologie moléculaire
Mots-clés Pascal anglais : Carcinoid tumor, Neuroendocrine tumor, Comparative study, Hormonal regulation, Clinical investigation, Characteristics, Foregut, Midgut, Hindgut, Survival, Human, Tumor, Digestive diseases, Intestinal disease, Molecular biology
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0074150
Code Inist : 002B13B01. Création : 31/05/1999.