Serum follicle-stimulating hormone (FSH), luteinizing honnone (LH), and testosterone levels, as well as urinary levels of FSH, LH, and E1C, a metabolite of testosterone, were measured to investigate the adverse reproductive effects of organophosphate pesticides among Chinese factory workers who were occupationally exposed to ethylparathion and methamidophos.
Thirty-four exposed workers were randomly chosen and recruited from a large pesticide factory, and 44 unexposed workers were selected from a nearby textile factory.
A quantitative pesticide exposure assessment was performed among a subset of the exposed and unexposed workers.
Information on potential confounders was collected in an interview.
A single blood sample was collected at the end of a work shift, when each subject also donated a semen sample.
Three first-voided urine samples were collected from each worker on 3 consecutive days.
Urinary p-nitrophenol level at I hour after the work shift correlated with serum (r=0. 71, P<0.01) and urinary (r=0.51, P=0.04) FSH levels.
Stratifying by the subjects'exposure status, we found a significant negative correlation among the exposed group between urinary FSH level and sperm count (r=-0.61, P<0.01) and between urinary FSH level and sperm concentration (r=-0.53, P=0.03).
Pesticide exposure alone was significantly associated with serum LH level (bêta [coefficient of exposure effect=0.79 ; 95% confidence interval [CI]=0.42,1. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Industrie chimique, Pesticide, Organophosphoré, Homme, Etude cas témoin, Surveillance biologique, Toxicité, Hormone stéroïde sexuelle, Marqueur biologique, Liquide biologique, Sang, Urine, Potentiel reproducteur, Analyse statistique, Corrélation
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Chemical industry, Pesticides, Organophosphorus compounds, Human, Case control study, Biological monitoring, Toxicity, Sex steroid hormone, Biological marker, Biological fluid, Blood, Urine, Reproductive potential, Statistical analysis, Correlation
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0074143
Code Inist : 002B03G. Création : 31/05/1999.