Background A program for banking, characterizing, and distributing placental blood, also called umbilical-cord blood, for transplantation provided grafts for 562 patients between August 24,1992, and January 30,1998.
We evaluated this experience.
Methods Placental blood was stored under liquid nitrogen and selected for specific patients on the basis of HLA type and leukocyte content.
Patients were prepared for the transplantation of allogeneic hematopoietic cells in the placental blood and received prophylaxis against graft-versus-host disease (GVHD) according to routine procedures at each center.
Results Outcomes at 100 days after transplantation were known for all 562 patients, and outcomes at 1 year for 94 percent of eligible recipients.
The cumulative rates of engraftment among the recipients, according to actuarial analysis, were 81 percent by day 42 for neutrophils (median time to engraftment, 28 days) and 85 percent by day 180 for platelets (median, day 90).
The speed of myeloid engraftment was associated primarily with the leukocyte content of the graft, whereas transplantation-related events were associated with the patient's underlying disease and age, the number of leukocytes in the graft, the degree of HLA disparity, and the transplantation center.
After engraftment, age, HLA disparity, and center were the primary predictors of outcome.
Severe acute GVHD (grade III or IV) occurred in 23 percent of patients, and chronic GVHD occurred in 25 percent. (...)
Mots-clés Pascal : Transfusion, Placenta, Sang, Cellule souche, Cellule hématopoïétique, Histocompatibilité, Maladie greffon hôte, Chimioprophylaxie, Traitement, Pronostic, Etude statistique, New York, Etats Unis, Amérique du Nord, Amérique, Enfant, Homme, Adulte, Immunopathologie
Mots-clés Pascal anglais : Transfusion, Placenta, Blood, Stem cell, Hematopoietic cell, Histocompatibility, Graft versus host reaction, Chemoprophylaxis, Treatment, Prognosis, Statistical study, New York, United States, North America, America, Child, Human, Adult, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0071888
Code Inist : 002B27D02. Création : 31/05/1999.