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  1. Intensive lifestyle changes for reversal of coronary heart disease.

    Article - En anglais

    Context. - The Lifestyle Heart Trial demonstrated that intensive lifestyle changes may lead to regression of coronary atherosclerosis after 1 year.

    Objectives

    - To determine the feasibility of patients to sustain intensive lifestyle changes for a total of 5 years and the effects of these lifestyle changes (without lipid-lowering drugs) on coronary heart disease.

    Design

    - Randomized controlled trial conducted from 1986 to 1992 using a randomized invitational design.

    Patients

    - Forty-eight patients with moderate to severe coronary heart disease were randomized to an intensive lifestyle change group or to a usual-care control group, and 35 completed the 5-year follow-up quantitative coronary arteriography.

    Setting

    - Two tertiary care university medical centers.

    Intervention

    - lntensive lifestyle changes (10% fat whole foods vegetarian diet, aerobic exercise, stress management training, smoking cessation, group psychosocial support) for 5 years.

    Main Outcome Measures

    - Adherence to intensive lifestyle changes, changes in coronary artery percent diameter stenosis, and cardiac events.

    Results

    - Experimental group patients (20 [71% ] of 28 patients completed 5-year follow-up) made and maintained comprehensive lifestyle changes for 5 years, whereas control group patients (15 [75% ] of 20 patients completed 5-year follow-up) made more moderate changes.

    In the experimental group, the average percent diameter stenosis at baseline decreased 1. (...)

    Mots-clés Pascal : Cardiopathie coronaire, Facteur risque, Réversibilité, Athérosclérose, Changement comportement, Effet milieu, Comportement alimentaire, Etude statistique, Randomisation, Etude comparative, Mode de vie, Adulte, Homme, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Coronary heart disease, Risk factor, Reversibility, Atherosclerosis, Behavior change, Medium effect, Feeding behavior, Statistical study, Randomization, Comparative study, Life style, Adult, Human, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0070835

    Code Inist : 002B12A03. Création : 31/05/1999.