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  1. Intra-abdominal Candida infection during acute necrotizing pancreatitis has a high prevalence and is associated with increased mortality.

    Article - En anglais

    Objectives 

    To analyze the frequency of intra-abdominal Candida infection during acute necrotizing pancreatitis and to compare the outcome to patients without Candida Infections.

    Design 

    Retrospective analysis of data from 37 patients with and without Candida infection.

    Setting 

    Surgical intensive care unit (ICU) in a university hospital.

    Patients 

    Thirty-seven patients with acute necrotizing pancreatitis.

    Interventions 

    Patients were subject to necrosectomy and programmed lavage.

    Measurements and Main Results 

    Clinical parameters contained in the Acute Physiology and Chronic Health Evaluation (APACHE) II score were monitored, as were microbiological results from the intra-abdominal primary focus and from sites of secondary infections.

    Body mass index, distribution of underlying diseases, length of ICU stay, number of operations, and outcome were recorded.

    Multivariate logistic regression analysis for mortality as the dependent variable was performed.

    Intra-abdominal Candida infection was observed in 13 of 37 cases and was associated with a four-fold greater mortality rate compared with intra-abdominal bacterial infection alone.

    Multivariate logistic regression analysis demonstrated that Candida Infection contributed to mortality significantly (p<. 025) and independently from APACHE II (p<. 006 ; mortality odds ratio for the two parameters=12.5).

    Lack of antimycotic treatment was associated with an increase to 29.2 (p<. 001) in the odds ratio. (...)

    Mots-clés Pascal : Pancréatite, Nécrose, Aigu, Candida, Fungi Imperfecti, Fungi, Thallophyta, Mycose, Infection, Septique syndrome, Abdomen, Unité soin intensif, Epidémiologie, Prévalence, Mortalité, Taux, Homme, Allemagne, Europe, Appareil digestif pathologie, Pancréas pathologie, Abdomen pathologie, Soin intensif

    Mots-clés Pascal anglais : Pancreatitis, Necrosis, Acute, Candida, Fungi Imperfecti, Fungi, Thallophyta, Mycosis, Infection, Sepsis syndrome, Abdomen, Intensive care unit, Epidemiology, Prevalence, Mortality, Rate, Human, Germany, Europe, Digestive diseases, Pancreatic disease, Abdominal disease, Intensive care

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0070362

    Code Inist : 002B13C03. Création : 31/05/1999.