The control of exposure to hazardous substances in the workplace has traditionally focused on uptake via the inhalation route.
Control of skin uptake has generally been considered for solids and liquids but the potential for uptake from vapours and gases has received relatively little attention.
The current work was undertaken to establish a methodology to study the dermal uptake from vapours and to provide new and comparative information on a range of substance vapours.
Groups of human volunteers were exposed to a small range of substances either'whole body'or via the skin only.
Substances (xylene, toluene, tetrahydrofuran [THF], methyl ethyl ketone [MEK] and 1-methoxypropan-2-ol [M2P]) were selected on the basis of their predicted dermal uptake from the vapour phase ; their industrial use and potential for occupational exposure ; the existence of a health-based occupational exposure limit ; the availability of an analytical technique (s) for the substance and/or metabolite (s) ; and as representatives of chemical classes.
Exposures were for four hours generally at the level of the UK Occupational Exposure Standard.
Uptake was assessed by monitoring of parent or metabolite in blood, single breath or urine following exposure.
Uptake of xylene, toluene and THF vapours via the skin under the conditions of this study was estimated to contribute around 1-2% of the body burden received following whole body (including inhalation) exposure. (...)
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Médecine travail, Homme, Voie percutanée, Pénétration, Absorption, Peau, Volontaire, Pollution intérieur, Phase vapeur, Dépôt phase vapeur, Airborne
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Occupational medicine, Human, Percutaneous route, Penetration, Absorption, Skin, Volunteer, Indoor pollution, Vapor phase, Vapor deposition
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0068062
Code Inist : 002B03L04. Création : 31/05/1999.