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  1. Benzene in environmental air and human blood.

    Article - En anglais

    Objective 

    To study the blood benzene levels resulting from environmental and occupational benzene exposure.

    Methods 

    Benzene in venous blood was measured in 243 nonoccupationally exposed subjects ( normal'people) and in 167 workers occupationally exposed to benzene.

    All exposed workers gave blood samples at the end of the work shift and on the following morning before resuming work.

    Blood benzene was assayed by gas chromatography (GC) - mass spectrometry.

    Occupational benzene exposure was monitored by environmental personal samplers and measured by GC analysis.

    Results 

    The mean occupational benzene exposure for all 167 workers studied was 186 ng/l (58 ppb ; range 5-1535 ng/l, 2-500 ppb).

    Overall, the mean blood benzene level of all workers was 420 ng/l at the end of the shift and 287 ng/l on the morning thereafter.

    The blood benzene levels measured the morning after turned out to be significantly lower (t=3.6 ; P<0.0001) than those measured at the end of the shift.

    The mean blood benzene level of the 243 « normal »subjects was 165 ng/l, which was significantly lower than that measured in the workers on the morning thereafter (t=5.8 ; P<0.0000001).

    The mean blood benzene concentration was significantly higher in smokers than in nonsmokers in both the general population (264 versus 123 ng/l) and in the exposed workers. (...)

    Mots-clés Pascal : Benzène, Solvant organique, Exposition professionnelle, Médecine travail, Environnement, Etude cohorte, Homme, Surveillance biologique, Marqueur biologique, Liquide biologique, Sang, Teneur air ambiant, Tabagisme, Facteur risque

    Mots-clés Pascal anglais : Benzene, Organic solvent, Occupational exposure, Occupational medicine, Environment, Cohort study, Human, Biological monitoring, Biological marker, Biological fluid, Blood, Ambient air concentration, Tobacco smoking, Risk factor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0067812

    Code Inist : 002B03L04. Création : 31/05/1999.