Study of the cardiovascular effects of occupational exposure to organic solvents.
Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.
The objective of the present study was to evaluate the effects of occupational exposure to over-concentrations of some organic solvents on the prevalence of arterial hypertension (AH) and pathologic changes in electrocardiography (ECG).
We studied 345 workers (250 men) aged between 20 and 60 years at a petrochemical factory, and 345 age-and sex-matched controls with no occupational contact with chemical and physical factors.
According to the main chemical pollutants in the working environment, the exposed subjects were divided into three groups : group 1, exposed to benzene ; group 2, exposed to xylene and benzene, and group 3, exposed to phenol.
Physical examination of the heart and routine resting electrocardiography with 12 leads were performed.
The degree of AH was determined according to the classification of the American Heart Association (JNC-V, 1993).
Statistical analysis was carried out with a SPSS software package.
The mean values of systolic and diastolic blood pressure and the prevalence of AH were significantly higher than in control groups I and 2. The prevalence of AH was 30.51% [OR=2.44 ; 95% confidence interval (CI) 1.24-4.85 ; P=0.00541 in group I and 27.92% (OR=2.00 ; 95% CI 1.11-3.61 ; P=0.0136) in group 2. The same relationship was found for the prevalence of ECG abnormalities :
The mean values of systolic and diastolic blood pressure and the prevalence of AH were significantly higher than in control groups I and 2. The prevalence of AH was 30.51% [OR=2.44 ;
95% confidence interval (CI) 1.24-4.85 ;
group 1,17.7% (OR=2.34 ; 95% CI 0.99-5,63 ; P=0.0344) and group 2,18,83% (OR=2.75 ; 95% CI 1.28-5.97 ; P=0.0044). (...)
Mots-clés Pascal : Solvant organique, Exposition professionnelle, Médecine travail, Cardiopathie, Homme, Hypertension artérielle, Industrie pétrochimique, Etude cohorte, Composé aromatique, Prévalence, Toxicité, Analyse statistique, Facteur risque, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Organic solvent, Occupational exposure, Occupational medicine, Heart disease, Human, Hypertension, Petrochemical industry, Cohort study, Aromatic compound, Prevalence, Toxicity, Statistical analysis, Risk factor, Cardiovascular disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067674
Code Inist : 002B03L04. Création : 31/05/1999.