A cross-sectional observation of the health effects of hydrazine hydrate and differences of its metabolism by NAT2 polymorphism.
Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.
To summarize the results of two studies that attempted to clarify : (1) the health effects of hydrazine hydrate (HH) (N2H4.
H2O : CAS No. 7803-57-8) ; and (2) the influence of allelic polymorphism of N-acetyltransferase (NAT2) on the metabolism of HH.
A cross-sectional survey was carried out on 172 male HH-exposed workers and 125 male referent workers at five factories in Japan.
The biological half-lives of HH after 1 h of exposure were determined in 12 workers, four workers in each of three NAT2 phenotypes.
Clinical examinations were performed and acute and chronic subjective symptoms related to HH were examined by self-administered questionnaires.
NAT2 phenotypes were assessed.
No hydrazine was detected in either the breathing zones or the urine of the referent workers.
The mean hydrazine concentration in the breathing zones, hydrazine and acetylhydrazine in urine, and the cumulative exposure level were 0.0109 ppm, 0.8660 mumol/g. Cr, and 2.80 ppm-years, respectively.
There was no difference and no dose-dependent change in the health examination items between HH-exposed and referent workers after adjusting confounding factors, nor in terms of the differences of NAT2 phenotypes.
Of 90 subjective symptoms, complaints of nightmares were significantly related to HH exposure.
The half-life of urinary hydrazine and acetylhydrazine on rapid, intermediate, and slow phenotypes was 1.68,3.01, and 4.46 h, respectively. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Hydrazine, Industrie chimique, Homme, Etude cohorte, Toxicocinétique, Toxicité, Métabolisme, Comparaison interindividuelle, Phénotype acétylateur, Polymorphisme, Acyltransferases, Transferases, Enzyme, N-acetyltranferase
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Hydrazine, Chemical industry, Human, Cohort study, Toxicokinetics, Toxicity, Metabolism, Interindividual comparison, Acetylator phenotype, Polymorphism, Acyltransferases, Transferases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067665
Code Inist : 002B03L06. Création : 31/05/1999.