Determination of trinitrotoluene and metabolites in urine by means of gas-chromatography with mass detection.
Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.
Biological monitoring of chemicals and/or their metabolites has been a recent development in South Africa with the publication of the Hazardous Chemical Substance Regulations in 1995.
Although trinitrotoluene (TNT) exposure has been included in recent legislative developments, only occupational exposure limits have been set.
TNT does not have a biological exposure index in South Africa or internationally.
This study was conducted to determine levels of TNT and its metabolite excretion in a sample of munition workers by using gas-chromatography with mass detection methodology.
The metabolites 4-amino-2.6-dinitrotoluene (4ADNT) and 2-amino-4.6-dinitrotoluene (2ADNT) in urine of exposed subjects, as well as total TNT (the sum of 4ADNT and 2 ADNT), were used to determine absorption and excretion due to TNT exposure.
Results indicated an increased absorption of TNT during the working week as compared to other published international studies.
Post-shift values exceeded pre-shift levels in all samples.
More reliable and specific research is necessary to set a biological threshold limit for TNT and its metabolites since monitoring indicated no definite symptoms, signs or biological effects due to increased excretion.
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Toluène(trinitro), Réactif chimique, Industrie, Armement, Surveillance biologique, Marqueur biologique, Liquide biologique, Urine, Métabolite, Toxicocinétique, Teneur air ambiant, Lieu travail, Homme
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Trinitrotoluene, Chemical reagent, Industry, Armament, Biological monitoring, Biological marker, Biological fluid, Urine, Metabolite, Toxicokinetics, Ambient air concentration, Work place, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067663
Code Inist : 002B03L06. Création : 31/05/1999.