To analyze whether indices of nasal airway inflammation in bakers were related to nasal symptoms and exposure to airborne flour dust.
A cross-sectional study was performed in 12 currently flour-exposed bakers.
They were examined by nasal lavage (NAL), visual inspection, a test of mucociliary clearance, and nasal peak expiratory flow (nasal PEF).
NAL fluid was analyzed according to the inflammatory markers eosinophil cationic protein (ECP), indicating eosinophilic activity ; myeloperoxidase (MPO), indicating active neutrophils ; hyaluronic acid (HA) from active fibroblasts ; tryptase, indicating activation of mast cells ; and albumin, indicating plasma exudation.
The bakers were also questioned about respiratory symptoms and working history.
Their current and cumulative exposure to inhalable flour dust was estimated after exposure measurements and information about earlier work tasks.
Office workers (n=16) without occupational exposure to dust or any other known nasal irritant or sensitizer served as controls.
Personal inhalable dust measurements among the bakers working as dough makers or bread formers ranged from 1.0 to 3.8 mg/m3.
Of the 12 bakers, 10 reported at least I nasal symptom (crusts, blockage, or a runny nose), a proportion significantly greater than that of the controls (P=0.009).
Bakers with nasal symptoms had higher concentrations of markers of inflammation in their NALs as compared with nonsymptomatic bakers. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Boulanger, Farine, Poussière, Rhinite, Inflammation, Homme, Etude cohorte, Teneur air ambiant, Surveillance biologique, Marqueur biologique, Lavage, Fosse nasale, Relation dose réponse, Analyse multivariable, Analyse statistique, ORL pathologie, Nez pathologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Baker, Flour, Dust, Rhinitis, Inflammation, Human, Cohort study, Ambient air concentration, Biological monitoring, Biological marker, Washing, Nasal fossa, Dose activity relation, Multivariate analysis, Statistical analysis, ENT disease, Nose disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067644
Code Inist : 002B03L03. Création : 31/05/1999.