The metabolism and toxicokinetics of cyclohexane (CH) and cyclohexanol (CH-ol), important solvents and chemical intermediates, were studied in volunteers after 8-h periods of inhalation exposure at concentrations of 1010 and 236 mg m-3, respectively (occupational exposure limits : CH, 1050 mg m-3 ; CH-ol, 200 mg m-3).
Of the dose of absorbed parent compounds, the yields of urinary CH-ol and 1,2-and 1,4-cyclohexanediol (CH-diol) were 0.5%, 23.4%, and 11.3%, respectively, after exposure to CH and 1.1%, 19.1%, and 8.4%, respectively, after exposure to CH-ol as determined by a gas chromatography method involving hydrolysis of glucuronide conjugates.
The metabolic patterns of CH and CH-ol were very similar to that of cyclohexanone (CH-one) studied in the laboratory previously.
For all three compounds, peak excretion of CH-ol occurred at the end of the exposure period, after which it decayed rapidly.
Excretion curves of 1,2-and 1,4-CH-diol reached maximal values within 0-6 h postexposure, with subsequent elimination half-lives being 14-18 h. The rate-limiting step in the elimination of CH compounds from the organism is renal clearance of CH-diols.
Determination of CH-diols in end-of-shift urine samples is recommended as a useful new method of biomonitoring of CH, CH-ol, and CH-one at the workplace. (...)
Mots-clés Pascal : Cyclohexane dérivé, Exposition, Métabolite, Surveillance biologique, Marqueur biologique, Inhalation, Liquide biologique, Urine, Diol, Médecine travail, Homme, Toxicocinétique
Mots-clés Pascal anglais : Cyclohexane derivatives, Exposure, Metabolite, Biological monitoring, Biological marker, Inhalation, Biological fluid, Urine, Diol, Occupational medicine, Human, Toxicokinetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067222
Code Inist : 002B03L04. Création : 31/05/1999.