Carcinogenic chemicals in the work area are currently classified into three categories in section III of the German List of MAK and BAT Values (list of values on maximum workplace concentrations and biological tolerance for occupational exposures).
This classification is based on qualitative criteria and reflects essentially the weight of evidence available for judging the carcinogenic potential of the chemicals.
It is proposed that these categories IIIAI, IIIA2, IIIB - be retained as Categories 1,2, and 3, to correspond with European Union regulations.
On the basis of our advancing knowledge of reaction mechanisms and the potency of carcinogens, these three categories are supplemented with two additional categories.
The essential feature of substances classified in the new categories is that exposure to these chemicals does not contribute significantly to risk of cancer to man, provided that an appropriate exposure limit (MAK value) is observed.
Chemicals known to act typically by nongenotoxic mechanisms and for which information is available that allows evaluation of the effects of low-dose exposures, are classified in Category 4. Genotoxic chemicals for which low carcinogenic potency can be expected on the basis of dose-response relationships and toxicokinetics, and for which risk at low doses can be assessed are classified in Category 5. (...)
Mots-clés Pascal : Médecine travail, Composé chimique, Carcinogène, Classification, Réglementation, Concentration maximale admissible, Seuil tolérance, Allemagne, Europe, Toxique, Critère sélection
Mots-clés Pascal anglais : Occupational medicine, Chemical compound, Carcinogen, Classification, Regulation, Maximum permissible concentration, Tolerable level, Germany, Europe, Poison, Selection criterion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067128
Code Inist : 002B30B01A. Création : 31/05/1999.