Sister chromatid exchange induced by chromium compounds in human lymphocytes.
The objective of this study was to study was to compare chromium (Cr), nickel-chromium (Ni-Cr), and control groups for sister chromatid exchange (SCE) in lymphocytes to obtain an understanding of the mutagenic effect of Cr (VI) in humans.
Subjects totaled 91 persons from the 3 groups, including 14 Cr and 34 Ni-Cr electroplating workers and 43 control group members.
Results showed that blood and urine Cr concentrations were highest among Cr workers (11.39 mug/l, 14.7 mug/g creatinine), next highest among Ni-Cr workers (5.28 mug/l, 6.2 mug/g creatinine), and lowest among the control group (2.36 mug/l, NA).
After adjustment for smoking habits, SCE/cell values were 10.6,9.4, and 8.3 for Cr workers, Ni-Cr workers, and controls, respectively.
A synergetic effect was shown on HFC (high-frequency cells) percentages for Cr workers who also smoked.
Odds ratios were 31.78 and 3.66 that Cr and Ni-Cr workers would have higher HFC percentages than the control group, respectively.
The authors conclude that SCE in lymphocytes is useful for evaluation of the biological effects of environmental mutagens. failed to find a consistent relationship between SCE frequency results and Cr exposure concentrations.
Nagaya et al. found Cr exposure to be unrelated to urine Cr concentrations in a 1989 study.
Then, in a 1991 study, Nagaya et al. found SCE frequencies to be unrelated to urine Cr concentrations. (...)
Mots-clés Pascal : Chrome composé, Chrome VI, Exposition professionnelle, Médecine travail, Industrie, Dépôt électrolytique, Mutagenèse, Toxicité, Homme, Etude cohorte, Echange chromatide soeur, Surveillance biologique, Marqueur biologique, Lymphocyte
Mots-clés Pascal anglais : Chromium compound, Chromium VI, Occupational exposure, Occupational medicine, Industry, Electrodeposition, Mutagenesis, Toxicity, Human, Cohort study, Sister chromatid exchange, Biological monitoring, Biological marker, Lymphocyte
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0067127
Code Inist : 002B03N. Création : 31/05/1999.