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  1. A comparative assessment of liver function in workers in the petroleum industry.

    Article, Communication - En anglais

    Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.


    The group studied included 666 workers from the benzene (n=30), xylenes (n=144), ethylene oxide (n=91), 1,3-butadiene (n=110) and transport and mechanisation (n=X2) departments of a petrochemical plant in Bulgaria.

    The leading hazards for the particular departments are as follows :

    • Benzene : benzene (up to ten times the threshold limit value ; TLV) : xylenes : benzene (up to nine times TLV) and xylenes (up to 1.6 times TLV) ;

    • ethylene oxide : ethylene oxide (up to 20 times TLV) and ethylene (up to 30 times TLV) ;

    • divinyl : 1,3-butadiene (five times TLV) and acetonitrile (six times TLV) ;

    • transport and mechanisation : benzene, xylenes and pentane (0.7-10 times TLV).


    The functional status of the liver was assessed by clinical (medical checkup), echographic and biochemical (ASAT, ALAT, APh, y-GT, lipid fractions, reduced glutathione and SH groups) investigations.

    Biochemical analyses were performed with POINTE 190 (USA).

    The results obtained were compared with those of a control group (n=150), consisting of subjects with no occupational exposure to chemical hazards.


    Comparisons showed that the metabolic disturbances determined were most significant in workers from the ethylene oxide department.

    Significant decreases in the serum levels of reduced glutathione (up to 48%) and of thiol groups (with 23%), increased enyzme activity (up to 18%) and lipid fractions (up to 24%) were observed. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Composé chimique, Industrie pétrolière, Homme, Fonction hépatique, Evaluation, Comparaison interindividuelle, Poste travail, Facteur risque

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Chemical compound, Oil industry, Human, Liver function, Evaluation, Interindividual comparison, Workplace layout, Risk factor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0067102

    Code Inist : 002B03L06. Création : 31/05/1999.