Hemolytic crisis in G6PD-deficient individuals in the occupational setting.
Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects an estimated 400 million people.
Most of the individuals affected live in Africa, the Middle East and Southeast Asia, or are African-Americans.
The ethnic distribution of G6PD-deficiency is extremely variable in Israel - where the Jewish population has been repatriated from more than 60 different countries - its prevalence being from 0% to 58%. Five cases of hemolytic episodes arising from the loading of trinitrotoluene (TNT) were detected.
Hemoglobin levels dropped between 4 and 10.2 g/dl.
Reticulocytosis reached 4% - 26.2% of red blood cells, while bilirubin levels rose to a peak of 5. 1 mg/dl.
Methemoglobin was 1.5% - 8.6% and sulfmethemoglobin 0.9% - 4.93% of total hemoglobin.
Urinary urobilinogen was increased in all.
All five workers showed absolute G6PD deficiency.
In one worker a urinary metabolite of TNT 2-6 dinitromono amino toluene, was detected.
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Toluène(trinitro), Industrie chimique, Toxicité, Déficit, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Hémolyse réactive, Facteur risque, Génotype, Génétique, Ethnie, Israël, Asie, Etude cas témoin, Homme, Hémopathie, Anémie hémolytique, Métabolisme pathologie, Enzymopathie, Maladie héréditaire
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Trinitrotoluene, Chemical industry, Toxicity, Deficiency, Glucose-6-phosphate 1-dehydrogenase, Oxidoreductases, Enzyme, Reactive hemolysis, Risk factor, Genotype, Genetics, Ethnic group, Israel, Asia, Case control study, Human, Hemopathy, Hemolytic anemia, Metabolic diseases, Enzymopathy, Genetic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0066770
Code Inist : 002B03L06. Création : 31/05/1999.