Biological monitoring of occupational exposure to arsenic by determining urinary content of inorganic arsenic and its methylated metabolites.
Medichem 1997 : Silver Jubilee Medichem Congress on Occupational and Environmental Health in the Chemical Industry. Varna, BGR, 1997/09/30.
A study was undertaken to assess the relationship between inhalation exposure to arsenic in copper smeltery workers and urinary excretion of total inorganic arsenic metabolites (Asitm), including inorganic arsenic (Asi), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA).
The methods applied made it possible, in principle, to determine all forms of airborne arsenic and to eliminate the influence of seafood-derived organoarsenicals on the level of urinary Asitm.
Air samples were collected on the second day of work after the weekend break.
Urine samples were collected just after shift-end on the same workday.
The time-weighted average (TWA) concentrations of arsenic in the workers'breathing zone varied between I and 746 mug/m3 and Asitm concentrations in urine between 2 and 850 mug/l (s.g. 1.024).
The urine samples with a specific gravity of lower than 1.010 and higher than 1.030 were not considered ; neither were those subjects with an Asitm excretion efficiency of higher than 100% of the dose absorbed during the day of measurement.
In total, 53 air samples and corresponding urine samples were obtained.
The correlation coefficient between the airborne arsenic concentration in mug/m3 (X) and the concentration of urinary Asitm in mug/l, s.g. 1.024 (Y), was 0.723.
The relation between the two variables can be presented using the following formula : Y=6.29 X0. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Arsenic, Industrie métallurgique, Homme, Surveillance biologique, Marqueur biologique, Métabolite, Liquide biologique, Urine, Teneur air ambiant, Lieu travail, Inhalation, Modèle régression
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Arsenic, Metallurgical industry, Human, Biological monitoring, Biological marker, Metabolite, Biological fluid, Urine, Ambient air concentration, Work place, Inhalation, Regression model
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0066762
Code Inist : 002B03L05. Création : 31/05/1999.