Uncontrolled, retrospective clinical studies have recently claimed that HCV infection could trigger the onset of diabetes mellitus (DM).
We sought to verify the association between DM and liver diseases of different etiology, stage, and severity in a prospective study including gender-and age-matched controls.
Two hundred forty-seven patients with liver cirrhosis (184 men, 116 with an associated hepatocellular carcinoma, 34% in Child-Pugh's class A) were evaluated (group 1).
One hundred fifty-seven (63.5) of them were HCV positive, 38 (15.5%) HBV positive, 49 (19.8%) alcohol abusers, and three (1.2%) cryptogenic.
Two control groups were also included.
The first control group consisted of 138 patients with chronic hepatitis due to HCV infection (73.9%), HBV infection (15.9%), or alcohol abuse (10.2%) (group 2).
The second control group included 494 patients with an acute osteoarticular trauma, age-and gender-matched with patients in group 1 (group 3).
Diabetes mellitus was present in 32.3%, 3.6%, and 9.7% of patients in groups 1,2, and 3, respectively.
When compared with controls (group 3), DM was significantly less frequent in group 2 (p<0.004) and significantly more frequent in group 1 (p<0.0001).
The prevalence of DM was not different among patients with HCV, HBV infection, or alcohol abuse.
In group 3, the prevalence of DM appeared to increase steadily with age. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Incidence, Diabète, Association morbide, Prédisposition, Facteur risque, Corrélation, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Endocrinopathie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Incidence, Diabetes mellitus, Concomitant disease, Predisposition, Risk factor, Correlation, Epidemiology, Human, Digestive diseases, Hepatic disease, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0065405
Code Inist : 002B05C02G. Création : 31/05/1999.