We sought to examine whether anticipation (an earlier age of onset in succeeding generations) is observed in Crohn's disease (CD) patients within the New York metropolitan area, and whether there are differences in the degree of anticipation with respect to gender and ethnicity of the affected parent.
Sixty-one parent-child pairs both affected by CD were identified ; about half of the pairs were of Ashkenazi Jewish descent.
An additional 17 pairs of second-degree relatives with CD were also identified.
The intergenerational difference in age at diagnosis (AAD) was used to perform regression analysis and the degree of anticipation among subsets of patients separated on the basis of gender and ethnicity of the transmitting parent was determined.
The AAD was consistently (90% of the time) lower in the younger member of the 61 parent-child pairs (35.3 ± 1.6 yr vs 20.8 ± 1.1 yr, p=0.0001).
Furthermore, the degree of anticipation was significantly greater for father-child pairs (20.6 ± 3.2 yr) than for mother-child pairs (11.7 ± 2.1 yr).
However, when the patient population where the parent had an AAD of<28 was analyzed separately, there was a lack of clear-cut evidence of anticipation in the population as a whole.
Only when the population was subdivided by ethnicity was there convincing evidence of anticipation in the Jewish population. (...)
Mots-clés Pascal : Entérite Crohn, Héréditaire, Facteur risque, Evolution, Age apparition, Sexe, Parent, Origine ethnique, Epidémiologie, Homme, Appareil digestif pathologie, Intestin pathologie, Maladie inflammatoire
Mots-clés Pascal anglais : Crohn disease, Hereditary, Risk factor, Evolution, Age of onset, Sex, Parent, Ethnic origin, Epidemiology, Human, Digestive diseases, Intestinal disease, Inflammatory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0063316
Code Inist : 002B13B03. Création : 31/05/1999.