OBJECTIVE The aim of the study was to evaluate the impact on health-related quality of life (HRQoL) in untreated GHD patients using the disease-specific Assessment of Growth Hormone Deficiency in Adults (AGHDA) questionnaire.
DESIGN AND PATIENTS A cohort of 356 consecutive adult GHD patients, diagnosed after the age of 18 years, from the endocrinology units of 37 Spanish hospitals were included over a 6-month period in a longitudinal observational quality-of-life study.
In addition, patients'HRQoL scores were compared to those obtained from a random sample of 963 subjects from the general population recruited by trained interviewers in a 6-month period and matched by age and sex to figures of the 1991 Spanish census.
MEASUREMENTS Patients were evaluated at baseline and after 12-months.
Socio-demographic and health variables such as age, sex, level of education, income level, number of chronic diseases and self-reported health status were recorded at baseline and follow-up visits.
Patients underwent physical and analytical examination and completed the AGHDA questionnaire.
A survey including socio-demographic, self-reported health status and the AGHDA questionnaire was administered at the individuals'homes.
RESULTS Mean score for patients at baseline was 9.4 (Cl=8.4-10.4) and at 12 months 10 (Cl=8.8-11). (...)
Mots-clés Pascal : STH, Déficit, Qualité vie, Etude longitudinale, Etude comparative, Facteur sociodémographique, Epidémiologie, Espagne, Europe, Adulte, Homme, Personne âgée, Hormone adénohypophysaire, Endocrinopathie
Mots-clés Pascal anglais : Somatotropin hormone, Deficiency, Quality of life, Follow up study, Comparative study, Sociodemographic factor, Epidemiology, Spain, Europe, Adult, Human, Elderly, Adenohypophyseal hormone, Endocrinopathy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0063202
Code Inist : 002B30A01A2. Création : 31/05/1999.