Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer.
In a recent randomized intervention trial, the risk of prostate cancer for men receiving a daily supplement of 200 mug selenium was one third of that for men receiving placebo.
By use of a nested case-control design within a prospective study, i.e., the Health Professionals Follow-Up Study, we investigated the association between risk of prostate cancer and prediagnostic level of selenium in toenails, a measure of long-term selenium intake.
In 1986,51529 male health professionals aged 40-75 years responded to a mailed questionnaire to form the prospective study.
In 1987,33737 cohort members provided toenail clippings.
In 1988,1990,1992, and 1994, follow-up questionnaires were mailed.
From 1989 through 1994,181 new cases of advanced prostate cancer were reported.
Case and control subjects were matched by age, smoking status, and month of toenail return.
Selenium levels were determined by neutron activation.
All P values are two-sided.
The selenium level in toenails varied substantially among men, with quintile medians ranging from 0.66 to 1.14 mug/g for control subjects.
When matched case-control data were analyzed, higher selenium levels were associated with a reduced risk of advanced prostate cancer (odds ratio [OR] for comparison of highest to lowest quintile=0.49 ; 95% confidence interval [CI]=0.25-0.96 ; P for trend=11). (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Stade avancé, Facteur risque, Epidémiologie, Sélénium, Orteil, Ongle, Etude cas témoin, Etats Unis, Amérique du Nord, Amérique, Homme, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Advanced stage, Risk factor, Epidemiology, Selenium, Toe, Nail(anatomy), Case control study, United States, North America, America, Human, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0062959
Code Inist : 002B14D02. Création : 31/05/1999.