To examine population mean variations in plasma fibrinogen and fibrinolytic variables, and their rela tions with cardiovascular risk characteristics among Japanese middle-aged men, a cross-sectional study was conducted for a total of 245 men aged 50-59 years in three population-based samples : residents in rural communities of northeast and central Japan and urban white-collar workers.
Age-adjusted mean value of plasma fibrinogen, tissue plasminogen activator antigen (t-PA antigen), plasminogen activator inhibitor 1 antigen (PAI-1 antigen) did not differ significantly among the populations.
Mean value of tissue plasminogen activator activity (t-PA activity) was lower in central rural residents than in northeast rural men.
According to multiple linear regression analyses, there were positive associations of t-PA and PAI-1 antigens with serum triglyceride levels, serum insulin and waist-hip ratio within each population and the total samples.
A positive association between these fibrinolytic variables and usual ethanol intake was also observed.
Smoking was significantly associated with plasma fibrinogen and PAI-1 antigen but not with t-PA antigen or activity, Activity of t-PA was inversely associated with body mass index, and a mean difference in t-PA activity was in part explained by a mean difference in body mass index. (...)
Mots-clés Pascal : Cardiopathie, Etude transversale, Facteur risque, Fibrinogène, Inhibiteur plasminogen activator 1, Analyse biochimique, Insuline, Résistance, Age 50-59, Population, Japon, Asie, Echantillon, Homme, Evaluation, Appareil circulatoire pathologie, Hématologie
Mots-clés Pascal anglais : Heart disease, Cross sectional study, Risk factor, Fibrinogen, Plasminogen activator inhibitor 1, Biochemical analysis, Insulin, Resistance, Age 50-59, Population, Japan, Asia, Sample, Human, Evaluation, Cardiovascular disease, Hematology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0062371
Code Inist : 002B12A03. Création : 31/05/1999.