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  1. Plasma fibrinogen, tissue plasminogen activator, plasminogen activator inhibitor 1, and their related factors in three Japanese population samples.

    Article - En anglais

    To examine population mean variations in plasma fibrinogen and fibrinolytic variables, and their rela tions with cardiovascular risk characteristics among Japanese middle-aged men, a cross-sectional study was conducted for a total of 245 men aged 50-59 years in three population-based samples : residents in rural communities of northeast and central Japan and urban white-collar workers.

    Age-adjusted mean value of plasma fibrinogen, tissue plasminogen activator antigen (t-PA antigen), plasminogen activator inhibitor 1 antigen (PAI-1 antigen) did not differ significantly among the populations.

    Mean value of tissue plasminogen activator activity (t-PA activity) was lower in central rural residents than in northeast rural men.

    According to multiple linear regression analyses, there were positive associations of t-PA and PAI-1 antigens with serum triglyceride levels, serum insulin and waist-hip ratio within each population and the total samples.

    A positive association between these fibrinolytic variables and usual ethanol intake was also observed.

    Smoking was significantly associated with plasma fibrinogen and PAI-1 antigen but not with t-PA antigen or activity, Activity of t-PA was inversely associated with body mass index, and a mean difference in t-PA activity was in part explained by a mean difference in body mass index. (...)

    Mots-clés Pascal : Cardiopathie, Etude transversale, Facteur risque, Fibrinogène, Inhibiteur plasminogen activator 1, Analyse biochimique, Insuline, Résistance, Age 50-59, Population, Japon, Asie, Echantillon, Homme, Evaluation, Appareil circulatoire pathologie, Hématologie

    Mots-clés Pascal anglais : Heart disease, Cross sectional study, Risk factor, Fibrinogen, Plasminogen activator inhibitor 1, Biochemical analysis, Insulin, Resistance, Age 50-59, Population, Japan, Asia, Sample, Human, Evaluation, Cardiovascular disease, Hematology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0062371

    Code Inist : 002B12A03. Création : 31/05/1999.