Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA-filtered helmets in reducing rhinoconjunctival and asthmatic reactions.
There are few data relating latex aeroallergen concentrations to biologic responses in latex-sensitized persons.
We sought to investigate acceptable latex aeroallergen concentrations below which latex-sensitive health care workers do not experience symptoms and to study the effect of high-efficiency particle arrest (HEPA) - filtered laminar flow helmets in preventing latex-induced symptoms.
Under challenge chamber conditions, latex-sensitive health care workers underwent 7 sequential inhalation challenge tests by donning and discarding either vinyl gloves (challenge 1), low latex-allergen powder-free gloves (challenge 2), or high latex-allergen powdered gloves (challenges 3 to 7) for up to I hour.
Volunteers wore a laminar flow helmet during all challenges ; HEPA filters in the helmet were in place only during challenges 3 and 4. Flow-volume loops, symptom scores, and latex aeroallergen concentrations were measured before and during each test.
At 60 minutes, latex aeroallergen concentrations during challenges 3 to 7 (mean, 7600 ng/m3 ; range, 93 to 54,000 ng/m3) were significantly higher than during challenges 1 or 2 (mean, 65 ng/m3 ; range, nondetectable to 100 ng/m3) (P<. 001 During challenges 5 and 6, mean maximum percent falls in FEV1 (-16% and - 11%, respectively) were significantly greater compared with those measured during challenges 3 and 4 (-3% and - I%, respectively) (P=03). (...)
Mots-clés Pascal : Allergie, Latex, Caoutchouc naturel, Allergène, Pneumallergène, Agent santé, Test provocation, Concentration, Fonction respiratoire, Prévention, Flux air laminaire, Casque protection, Homme, Immunopathologie, Médecine travail
Mots-clés Pascal anglais : Allergy, Latex, Natural rubber, Allergen, Aeroallergen, Health worker, Provocation test, Concentration, Lung function, Prevention, Air laminar flow, Crash helmet, Human, Immunopathology, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0061760
Code Inist : 002B06C01. Création : 31/05/1999.