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  1. Suprathreshold intensity and annoyance reactions in experimental challenge to toluene and n-butyl acetate among subjects with long-term solvent exposure.

    Article, Communication - En anglais

    Nordic Conference on the Work Environment and Health (NCWEH). Rebild Bakker, DNK, 1997/09/01.

    Objectives This study explores reactions to low-level chemical challenge, aiming at the development of test procedures for assessing individual sensitivity to smells and chemicals.

    Methods Subjects with symptoms and neuropsychological test results compatible with toxic encephalopathy type 2A (TE-2A) and 2B (TE-2B) and unexposed referents (N=12 in each group) were challenged in an exposure chamber.

    Toluene exposure was started at 1 1 mg/m3, and it followed a geometric progression scale with a ratio of 2, until reaching 180 mg/m3.

    In a counterbalanced design, the subjects were similarly exposed to n-butyl acetate starting at a concentration of 14 mg/m3 and increasing to 228 mg/m3.

    At each exposure level, smell intensity was measured on a 7-step category scale.

    Mucous membrane irritation and annoyance reactions were rated on visual analogue scales.

    Results Both TE groups showed high sensitivity to the low-level solvent challenge, which provoked immediate annoyance and fatigue reactions.

    In particular the TE-2B group related smell intensity to various annoyance dimensions during exposure to n-butyl acetate, a pattern not observed during toluene exposure.

    The reference group clearly separated smell intensity and annoyance reactions in both exposure conditions. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Toluène, Solvant organique, Homme, Encéphalopathie, Sensibilité, Evaluation, Odeur, Détection, Composé chimique, Etude cohorte, Gêne(nuisance), Détection seuil, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, n-Butyl(acétate)

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Toluene, Organic solvent, Human, Encephalopathy, Sensitivity, Evaluation, Odor, Detection, Chemical compound, Cohort study, Annoyance, Threshold detection, Nervous system diseases, Central nervous system disease, Cerebral disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0059268

    Code Inist : 002B30B01A. Création : 31/05/1999.