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  1. Asbestos lung burden and asbestosis after occupational and environmental exposure in an asbestos cement manufacturing area : a necropsy study.

    Article - En anglais


    The largest Italian asbestos cement factory had been active in Casale Monferrato until 1986 : in previous studies a substantial increase in the incidence of pleural mesothelioma was found among residents without occupational exposure to asbestos.

    To estimate exposure to asbestos in the population, this study evaluated the presence of histological asbestosis and the lung burden of asbestos fibres (AFs) and asbestos bodies (ABs).

    Methods-The study comprises the consecutive series of necropsies performed at the Hospital of Casale Monferrato between 1985 and 1988.

    A sample of lung parenchima was collected and stored for 48 out of 55 necropsies.

    The AF concentration was measured with a TEM electron microscope with x ray mineralogical analysis.

    The ABs were counted and fibrosis evaluated by optical microscopy.

    The nearest relative of each subject was interviewed on occupational and residential history.

    Mineralogical and histological analyses and interviews were conducted in 1993-4.


    Statistical analyses included 41 subjects with AF, AB count, and interview.

    Subjects without occupational exposure who ever lived in Casale Monferrato had an average concentration of 1500 AB/g dried weight (gdw) ; Seven of 18 presented with asbestosis or small airway lung disease (SAL).

    G2 asbestosis was diagnosed in two women with no occupational asbestos exposure.

    One of them had been teaching at a school close to the factory for 12 years. (...)

    Mots-clés Pascal : Exposition professionnelle, Médecine travail, Environnement, Industrie ciment, Amiante ciment, Asbestose, Surveillance, Autopsie, Corps asbestosique, Fibre amiante, Comptage, Etude cohorte, Homme, Anatomopathologie, Appareil respiratoire pathologie, Pneumoconiose, Maladie professionnelle, Poumon pathologie

    Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Environment, Cement industry, Asbestos cement, Asbestosis, Surveillance, Autopsy, Asbestos body, Asbestos fiber, Counting, Cohort study, Human, Pathology, Respiratory disease, Pneumoconiosis, Occupational disease, Lung disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0058043

    Code Inist : 002B03L03. Création : 31/05/1999.