Proposal for the assessment of quantitative dermal exposure limits in occupational environments : part 2. Feasibility study for application in an exposure scenario for MDA by two different dermal exposure sampling methods.
To evaluate two different techniques for assessing dermal exposure to 4,4'-methylene dianiline (MDA) in a field study.
The results were used to test the applicability of a recently proposed quantitative dermal occupational exposure limit (DOEL) for MDA in a workplace scenario.
Methods-For two consecutive weeks six workers were monitored for exposure to MDA in a factory that made glass fibre reinforced resin pipes.
Dermal exposure of the hands and forearms was assessed during week 1 by a surrogate skin technique (cotton monitoring gloves) and during week 2 by a removal technique (hand wash).
As well as the dermal exposure sampling, biological monitoring, measurement of MDA excretion in urine over 24 hours, occurred during week 2. Surface contamination of the workplace and equipment was monitored qualitatively by colorimetric wipe samples.
Results and conclusions-Geometric means of daily exposure ranged from 81-1762 mug MDA for glove monitoring and from 84-1783 mug MDA for hand washes.
No significant differences, except for one worker, were found between exposure of the hands in weeks 1 and 2. Significant differences between the mean daily exposure of the hands (for both weeks and sampling methods) were found for all workers.
The results of the colorimetric wipe samples indicated a general contamination of the workplace and equipment. (...)
Mots-clés Pascal : Exposition professionnelle, Médecine travail, Surveillance, 4,4p-Méthylènedianiline, Industrie transformation plastique, Homme, Voie percutanée, Absorption, Dose limite, Estimation, Dose journalière, Surveillance biologique, Liquide biologique, Urine, Teneur air ambiant, Corrélation, Méthodologie
Mots-clés Pascal anglais : Occupational exposure, Occupational medicine, Surveillance, Plastics processing industry, Human, Percutaneous route, Absorption, Limit dose, Estimation, Daily dose, Biological monitoring, Biological fluid, Urine, Ambient air concentration, Correlation, Methodology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 99-0058032
Code Inist : 002B03L06. Création : 31/05/1999.