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  1. Clinical characteristics, treatment, and outcome of adult onset Still's disease in southern Chinese.

    Article - En anglais

    Objective

    To study the clinical characteristics, treatment outcome, and complications of patients with adult onset Still's disease (AOSD) in our local Chinese population.

    Methods

    Patients with AOSD were identified among others who attended our rheumatology clinics from 1967 to 1997 and were followed.

    Their clinical and laboratory features at presentation, treatment, and outcome were recorded and compared with other reported series.

    Results

    Sixteen patients with AOSD were identified.

    Eleven (69%) were female.

    Nine (56%) had onset of the disease between 16 and 35 years of age.

    The commonest presenting features were fever (100%), arthritis (94%), rash (85%), weight loss (69%), and sore throat (63%). Fifteen patients presented with pyrexia of unknown origin and the median duration of fever before the establishment of the diagnosis was 6 weeks (range 4-75).

    The acute phase response was marked in all patients with gross elevation of erythrocyte sedimentation rate (ESR).

    C-reactive protein (CRP), and complement levels.

    Hyperferritinemia (>5 times normal) was present in 90% of cases.

    Most patients (81%) required corticosteroid therapy and 85% of those steroid treated patients received additional disease modifying agents.

    The mean duration of followup of our patients was 93.3 months (range 8-362).

    Five (33%) had monocyclic systemic disease. 6 (40%) had polycyclic systemic disease, and 4 (27%) had frequent relapses that progressed to a chronic arthropathy.

    Conclusion

    (...)

    Mots-clés Pascal : Rhumatisme inflammatoire chronique Still, Age apparition, Adulte, Homme, Epidémiologie, Chinois, Symptomatologie, Traitement, Pronostic, Complication, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire

    Mots-clés Pascal anglais : Still disease, Age of onset, Adult, Human, Epidemiology, Chinese, Symptomatology, Treatment, Prognosis, Complication, Diseases of the osteoarticular system, Inflammatory joint disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 99-0057949

    Code Inist : 002B15D. Création : 31/05/1999.